A busy, yet loveable older woman with alcoholism In the context of the Naruto anime and manga series, Tsunade (綱手) is the name of the Fifth Hokage of Konohagakure, a powerful kunoichi (female ninja) and medical-nin. The name Tsunade itself, in Japanese, is associated with concepts of strength, determination, and confidence, and can be interpreted to mean "one who is like the young thunder," according to a baby name site. In the series, she is known for her exceptional medical ninjutsu skills, her leadership as Hokage, and her complex backstory involving the loss of loved ones.

Tsunade Senju is the Fifth Hokage of the Hidden Leaf Village: She is one-third of Konoha's Sannin and is regarded as the most powerful kunoichi and greatest medical ninja of her time.